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We also recognize that because of thevariety of research designs found in the literature, not all items on the checklist will be applicable to all research reports. However,the radiosensitivity of the hematopoietic system of mice to p53 activation suggeststhat such an approach would potentially exacerbate the toxicity that is associatedwith MDM2 antagonists.
Diagram of the sensory and supporting cells of the spiral organ of Corti. Although this motif is often found to mediatehomodimerization with developmentally regulated proteins, the SAM domain doesnot contribute to homodimerization in p63 and p73 [ 20]. NIA–Reagan cri-teria (The National Institute on Aging no rx Deltasone 1997), proposedin 1997, made a couple of important changes, includingincorporation of NFT—using Braak score (Braak andBraak, 1991), and included plaque estimates withoutregard to age, to allow for probability statements of thelikelihood that dementia occurs as a result of AD (high,intermediate, low).
Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H,Dikkes P, Sharpe A, McKeon F, Caput D (2000) p73-de?cient mice have neurological, phero-monal and in?ammatory defects but lack spontaneous tumours. The maximum imaging depth is not changed during an exam The maximum imaging depth is not changed during an exam. These tools have also been appliedto the design of optimal MDM2/MDMX inhibitors.