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    However,in the past 10 years, there has been an appreciableimprovement in survival to the extent that manycentres are now reporting survival rates of greaterthan 80 %

    However,in the past 10 years, there has been an appreciableimprovement in survival to the extent that manycentres are now reporting survival rates of greaterthan 80 %.

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    Second, wewill summarize how a second mutation can revert the deleterious effect of an initialp53 cancer-associated hotspot mutation [ 57].

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